From 16/02/2009 to 15/08/2014, Doctorate
From 16/02/2009 to 15/08/2014, Senior Research Fellow (Doctoral fellow)
Institute of Microbial Technology
From 03/09/2013 to 04/06/2014, Fulbright-Nehru Doctoral and Professional Research Fellow
University of Pennsylvania, USA
Protein Structure and Function
Animal Model Studies
Arif E, Sharma P, Solanki A, Mallik L, Rathore YS, Twal WO, Nath SK, Gandhi D, Holzman LB, Ostap M, Ashish and Nihalani D. Structural analysis of the Myo1c and Neph1 complex provides insight into the intracellular movement of Neph1. Mol Cell Biol. 2016 April 04. Pii: MCB. 00020-16 [Epub ahead of print]
Rathore YS*, Dhoke RR, Badmalia M, Sagar A and Ashish*. SAXS data based global shape analysis of trigger factor (TF) proteins from E. Coli, V. cholerae and P. frigidicola: Resolving the debate on the nature of monomeric and dimeric forms. J Phys Chem B. 2015 April 29; 119 (20): 6101-6112
Singh S, Rathore YS, Bhando T, Hade MD, Ashish and Dikshit KL. Bilobed shape of PadA reveals the connectivity from single to multi-domain bacterial plasminogen activators. Int J Biol Macromol. 2015 April 18; 78: 370-78
Solnaki AK, Rathore YS, Badmalia M, Dhoke RR, Nath SK, Nihalani D and Ashish. Global shape and ligand binding efficiency of the HIV-1 neutralizing antibodies differs from the ones which cannot neutralize. J Biol Chem 2014 Dec 12; 289 (50):34780-800
Kaur H, Singh S, Rathore YS, Sharma A, Furukawa K, Hohmann S, FNU A and Mondal AK. Differential role of HAMP-like linkers in regulating the functionality of the group III histidine kinase DhNik1p. J Biol Chem 2014 July 18; 289(29):20245-20258
Pandey K1/2, Dhoke RR1/2 overrides the need of calcium ions for the shape-function relationship of calmodulin: Resolving prevailing debates. J Phys Chem B. 2014 April 15;118(19):5059-74 , Rathore YS, Nath SK, Verma N, Bawa S and Ashish. Low pH overrides the need of calcium ions for the shape-function relationship of calmodulin: Resolving prevailing debates. J Phys Chem B. 2014 April 15; 118 (19):5059-74
Arif E, Rathore YS, Kumari B, FNU Ashish, Wong HN, Holzman LB, Nihalani D. Slit diaphragm protein Neph1 and its signaling: a novel therapeutic target for protection of podocytes against glomerular injury. J Biol Chem. 2014 April 4;289(14):9502-18
Pandey K, Rathore YS, Nath SK, Ashish. Towards strain-independent anti-influenza peptides: a SAXS- and modeling-based study. J Biomol Struct Dyn. 2014 ;32(11):1720-33
Singh S, Pandey K, Rathore YS, Sagar A, Pattnaik UB, Ashish. A communication network within the cytoplasmic domain of Toll-like receptors has remained conserved during evolution. J Biomol Struct Dyn. 2014;32(5): 694-700
Singh R, Rathore YS, Singh NS, Peddada N, Ashish, Raychaudhuri S. Substitution of glutamate residue by lysine in the dimerization domain affects DNA binding ability of HapR by inducing structural deformity in the DNA binding domain. PLoS One. 2013 Oct 14;8(10):e76033.
Peddada N, Sagar A, Rathore YS, Choudhary V, Pattnaik UB, Khatri N, Garg R, Ashish. Global shapes of F-actin depolymerization-competent minimal gelsolins: insight into the role of g2-g3 linker in pH/Ca2+ insensitivity of the first half. J Biol Chem. 2013 Sept 27, 288 (39): 28266-82.
Malhotra A, Dolma K, Kaur N, Rathore YS, Ashish, Mayilraj S, Choudhury AR. Biosynthesis of gold and silver nanoparticles using a novel marine strain of Stenotrophomonas. Bioresour Technol. 2013 Aug; 142:727-31.
Johnstone DB, Shegokar V, Nihalani D, Rathore YS, Mallik L, Ashish, Zare V, Ikizler HO, Powar R, Holzman LB. APOL1 Null Alleles from a Rural Village in India Do Not Correlate with Glomerulosclerosis. PLoS One. 2012;7(12):e51546
Mallik L1/2, Arif E1/2, Sharma P, Rathore YS, Wong HN, Holzman LB, Ashish, Nihalani D. Solution Structure Analysis of Cytoplasmic Domain of Podocyte Protein Neph1 Using Small/Wide Angle X-ray Scattering (SWAXS). J Biol Chem. 2012 Mar 16; 287(12):9441-53.
Rathore YS, Rehan M, Pandey K, Sahni G, Ashish. First structural model of full-length human tissue-plasminogen activator: a SAXS data-based modeling study. J Phys Chem B. 2012 Jan 12;116(1):496-502
Rathore YS, Solanki AK, Dhoke RR, Ashish. SAXS data analysis and modeling of tetravalent neutralizing antibody CD4-IgG2 -/+ HIV-1 gp120 revealed that first two gp120 bind to the same Fab arm. Biochem Biophys Res Commun. 2011 Dec 2;415(4):680-685
Ashish, Pandey K, Rathore YS. “Synthetic peptides capable of binding to influenza hemagglutinin protein”. WO2013/121441 A2, 22 August 2013
“Study of complex and macro-molecular systems using Small angle x-ray scattering”. ASBMB annual Meeting, April 2014, SanDiego, USA, American Society for Biochemistry and Molecular Biology (ASBMB)
“Myo1c, an unconventional motor that maintains glomerular filtration function". ASBMB 2013, April 2013, Boston, USA, American Society for Biochemistry and Molecular Biology (ASBMB)
Visualizing How “Borrowed” Salp15 Protects Causative Agent of Lyme Disease in Host”, UNDERSTANDING AND MANAGING PATHOGENIC MICROBES (UMPM-2010). January 2010, Chandigarh, India, Institute of Microbial Technology
Honors and Awards
ASBMB Graduate/Postdoctoral Travel Award 2014. (at San Diego, California, 25-30, 2014)
Fulbright-Nehru Doctoral and Professional Research Award (F-NDPR) 2013-2014. (Visiting research Fellow at University of Pennsylvania, Philadelphia from September 2013 to June 2014)
Joint CSIR-UGC Test for Junior Research Fellowship and Eligibility for Lectureship (NET), INDIA, held on 20-06-2010
Joint CSIR-UGC Test for Junior Research Fellowship and Eligibility for Lectureship (NET), INDIA, held on 20-12-2009
Joint CSIR-UGC Test for Junior Research Fellowship and Eligibility for Lectureship (NET), INDIA, held on 20-06-2008.